Kunwarpal singh
Sri Guru Ram Das Institute of Medical Sciences and Research, India
Title: Role of conventional and diffusion weighted MRI with ADC values in staging of carcinoma of prostate and response to treatment wherever possible with clinical and biochemical correlation
Biography
Biography: Kunwarpal singh
Abstract
Background & Aim: Prostate cancer is one of the commonest malignancies in men that cause significant morbidity and mortality worldwide. The latest population-based cancer registry in India by ICMR records the age adjusted rate (AAR) to be 8.4, 10.7, 7.7,and 1.9 per 100,000 populations in the cities of Bangalore, Delhi, Mumbai and rural Barshi respectively. MRI is a powerful imaging modality for evaluation of anatomy and pathology of the prostate. This study aimed to evaluate the role of conventional MRI sequences
with diffusion weighted imaging using ADC values in staging of prostate carcinoma and in assessing response to treatment.
Materials & Methods: We prospectively studied 75 patients who came with suspicion of having carcinoma of prostate on Philips Gyroscan Achieva 1.5 Tesla MRI using sense body coil. Morphologic features of lesions were assessed on conventional sequences as well as on diffusion weighted imaging in pretreated and post treated patients. ADC values were calculated and statistically analysed.
Results: Highly significant correlation was found between serum PSA levels, prostate size, and staging and ADC values in both pretreated and post treated patients with p value <0.05. However, conventional weighted imaging did not show any significant change in signal intensity in post treated patients suggestive of added advantage of DWI.
Conclusions: MRI is a powerful imaging modality for comprehensive structural evaluation of anatomy and pathology of prostate
gland. Addition of ADC and DWI to T2WI provide more accurate results for prostate cancer detection, staging and post treatment
response.